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Aberrant DNA methylation associated with transcriptional abnormalities in cancer

Melanie Ehrlich, School of Medicine

Project Description

Using large state-of-the-art databases, we are studying relationships of abnormal DNA hypermethylation and hypomethylation in cancer to transcription. This research is uncovering insights into the functionality of these aberrations by comparing normal developmental changes in DNA methylation, chromatin epigenetics, and gene expression to those in cancer. Our findings are relevant to the discovery of novel cancer markers and development of cancer therapeutics as well as to furthering our understanding of how epigenetics drives and maintains differentiation. https://epigeneticssocietyint.com/message/president

Project Details

Faculty Supervisor Melanie Ehrlich
Project Start Date 08/13/2024
Number of Spots Available 1
Project Type Basic Science
Location Remote
Type of Research Data Analysis/Write-Up
Project Duration Medium-term (1-3 years)
Supervisor Faculty
Project Expertise https://medicine.tulane.edu/sites/default/files/pictures/PubsCurrectGrants_EhrlichM_For_TCC_2_2021_numbered_list_compliant.pdf

Prerequisites or Preferred Skills

  • Broad knowledge of Excel
  • Attention to detail
  • Broad knowledge of molecular genetics from a course and some knowledge of epigenetics, including DNA methylation, chromatin modifications, and open chromatin.

Expected Time Commitment

5

Required Forms

CV
Statement of interest in the project

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