Cooper Woods, School of Medicine
Diabetes induces vascular complications that greatly increase morbidity and mortality but are not attenuated by proper control of blood glucose. We previously demonstrated that diabetes increases two co-transcribed microRNAs, miR-221-3p and miR-222-3p (miR-221/222), in vascular smooth muscle cells (VSMCs) to promote intimal thickening. Diabetic VSMC-derived exosomes (DVEs) contain elevated levels of these miRNAs and modify endothelial and macrophage phenotypes to promote vascular inflammation and atherosclerotic plaque formation. The objective of this proposal is to determine the role of exosome mediated transfer of miR-221/222 in the micro- and macrovascular complications of diabetes.
| Faculty Supervisor | Cooper Woods |
| Project Start Date | |
| Number of Spots Available | |
| Project Type | Clinical |
| Location | On-Site |
| Type of Research | Animal-based, Lab-based |
| Project Duration | |
| Supervisor | Faculty |
| Project Expertise |
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