Gregory Macleod, School of Medicine
Mitochondria associate with the plasma membrane, and this has been observed in electron micrographs since the 1950s. This behavior is particularly evident in nerve terminals. However, the significance of this behavior is unknown. Working closely with a Research Scientist, you will be asked to culture motor neurons and use a sophisticated fluorescence microscopy platform to investigate the genetic basis and functional significance of this behavior. To facilitate this study, we have designed a novel binary fluorescent probe that reports close (<50nm) mitochondrial approach to the plasma membrane in live neurons.
| Faculty Supervisor | Gregory Macleod |
| Project Start Date | 09/02/2024 |
| Number of Spots Available | 2 |
| Project Type | Basic Science |
| Location | On-Site |
| Type of Research | Lab-based |
| Project Duration | Medium-term (1-3 years) |
| Supervisor | Post-doc |
| Project Expertise | https://themacleodlab.com/research/neuronal-energy-metabolism/ |
Attention to detail. Problem solving skills. Superior communication skills.
This project represents an opportunity to learn sophisticated modern microscopy techniques and an appropriate time commitment is expected, i.e. 16 hours/week.
Cover Letter and CV
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