Igor Rubtsov, Chemistry
We developed an approach of putting a unique vibrational label into a lipid bilayer at a desired depth in the hydrophobic portion of the bilayer. The label is capable of measuring accurately the rigidity of the bilayer via vibrational spectroscopy (FTIR and 2DIR). The project involved testing how the bilayer interior is affected by various antimicrobial agents, both water soluble and hydrophobic.
Check the following reference for more details: Md Muhaiminul Islam, Sithara U. Nawagamuwage, Igor V. Parshin, Margaret C. Richard, Alexander L. Burin, and Igor V. Rubtsov, Probing Hydrophobic Region of a Lipid Bilayer at Specific Depth Using Vibrational Spectroscopy, J. Am. Chem. Soc., 2023, 145, 48, 26363–26373; DOI: 10.1021/jacs.3c10178; https://pubs.acs.org/doi/full/10.1021/jacs.3c10178. The paper is featured in JACS Spotlights, 2023, 145, 48, 25927: https://pubs.acs.org/doi/10.1021/jacs.3c13307
New results, potential publications.
Time, eligibility, and other details
| Expected workload | One full day per week or equivalent. Perform measurements and data analysis. |
| Skills required | Strong knowledge in General Chemistry and/or Physics |
| Who is eligible | Sophomore or junior students |
| Core partners | N/A |
| Sponsoring party | faculty |
| Volunteer, Paid, or Credit-eligible? | Volunteering at first; can be credit eligible |
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