Project Description Numerous studies have been conducted on the influence of the pandemic on medical students’ academic performance. The breadth of these studies is as varied as their outcomes ranging from performance declines to no discernible effect or even improvement. A number of factors have been identified that negatively impacted students’ academic performance during […]

Project Description Medical students have been reported to have higher rates of burnout, anxiety, depressive symptoms and suicidal ideation as compared to age-matched general population (1) (2). To better address concerns about mental health among students, it is essential to first measure and understand it. To assess the mental health and well-being of medical students […]

Project Description Tissue resident macrophage function has emerged as a critical component controlling the balance between organ health and disease, and disruption of tissue homeostasis can lead to disease. Cancer cells adopt mechanisms to escape immune surveillance, evade growth signals, and others, by participating in complex interactions with healthy immune cells to orchestrate breast cancer […]

Project Description A specific and rapid cell ablation model mediated has been developed by my lab for nearly years. This ablation model was created by my lab via utilization of unique feature of bacterial toxin, intemedilysis (ILY)(Nat Med. 2008 Jan;14(1):98-103). ILY only lyzes human CD59 but not cells from any other species via exclusive interaction […]

Project Description The Department of Pediatrics (Tulane University School of Medicine) has numerous opportunities open for undergraduates. Some faculty have lab listings on TRN for specific projects – other students may be looking for opportunities beyond what is listed. Students interested in participating in pediatrics research should apply, including their general areas of interest (i.e. […]

Project Description Mitochondria associate with the plasma membrane, and this has been observed in electron micrographs since the 1950s. This behavior is particularly evident in nerve terminals. However, the significance of this behavior is unknown. Working closely with a Research Scientist, you will be asked to culture motor neurons and use a sophisticated fluorescence microscopy […]

Project Description Our lab focuses on the mechanobiology of lung injury, repair, and regeneration, investigating how biomechanical signals from the extracellular matrix (ECM) influence the progression and resolution of lung fibrosis. We have previously identified key roles of altered matrix mechanics in modulating gene expression and promoting the pro-fibrotic traits of lung fibroblasts and alveolar […]

Project Description The long-term goal of my research program is to uncover the epigenetic mechanisms, especially histone acetylation and deacetylation, responsible for kidney formation and abnormality. Our studies will provide new insights into the epigenetics of kidney development and open new avenues to novel strategies for the prevention and treatment of kidney diseases and associated […]

Project Description Diabetes induces vascular complications that greatly increase morbidity and mortality but are not attenuated by proper control of blood glucose. We previously demonstrated that diabetes increases two co-transcribed microRNAs, miR-221-3p and miR-222-3p (miR-221/222), in vascular smooth muscle cells (VSMCs) to promote intimal thickening. Diabetic VSMC-derived exosomes (DVEs) contain elevated levels of these miRNAs […]

Project Description Using large state-of-the-art databases, we are studying relationships of abnormal DNA hypermethylation and hypomethylation in cancer to transcription. This research is uncovering insights into the functionality of these aberrations by comparing normal developmental changes in DNA methylation, chromatin epigenetics, and gene expression to those in cancer. Our findings are relevant to the discovery […]