Project Description Our research focuses on the role of the gut microbiome in various conditions, including alcohol-associated liver disease, metabolic dysfunction-associated steatotic liver disease, liver fibrosis, inflammatory bowel disease, and colon and liver cancers. Additionally, we explore the therapeutic potential of cannabidiol in treating liver diseases and neurological disorders. A key area of interest […]

    Project Description One of the great questions in biology is why men and women differ in how they respond immunologically to various insults. It is known that women respond better to vaccines and many infections, yet this increased immune response often manifests in increased susceptibility to autoimmune disease in women compared to men. […]

Project Description Tissue resident macrophage function has emerged as a critical component controlling the balance between organ health and disease, and disruption of tissue homeostasis can lead to disease. Cancer cells adopt mechanisms to escape immune surveillance, evade growth signals, and others, by participating in complex interactions with healthy immune cells to orchestrate breast cancer […]

Project Description A specific and rapid cell ablation model mediated has been developed by my lab for nearly years. This ablation model was created by my lab via utilization of unique feature of bacterial toxin, intemedilysis (ILY)(Nat Med. 2008 Jan;14(1):98-103). ILY only lyzes human CD59 but not cells from any other species via exclusive interaction […]

Project Description Mitochondria associate with the plasma membrane, and this has been observed in electron micrographs since the 1950s. This behavior is particularly evident in nerve terminals. However, the significance of this behavior is unknown. Working closely with a Research Scientist, you will be asked to culture motor neurons and use a sophisticated fluorescence microscopy […]

Project Description Our lab focuses on the mechanobiology of lung injury, repair, and regeneration, investigating how biomechanical signals from the extracellular matrix (ECM) influence the progression and resolution of lung fibrosis. We have previously identified key roles of altered matrix mechanics in modulating gene expression and promoting the pro-fibrotic traits of lung fibroblasts and alveolar […]

Project Description The long-term goal of my research program is to uncover the epigenetic mechanisms, especially histone acetylation and deacetylation, responsible for kidney formation and abnormality. Our studies will provide new insights into the epigenetics of kidney development and open new avenues to novel strategies for the prevention and treatment of kidney diseases and associated […]

      Project Description Using large state-of-the-art databases, we are studying relationships of abnormal DNA hypermethylation and hypomethylation in cancer to transcription. This research is uncovering insights into the functionality of these aberrations by comparing normal developmental changes in DNA methylation, chromatin epigenetics, and gene expression to those in cancer. Our findings are relevant […]

Project Description Stem cells play pivotal roles in maintaining tissue and organ homeostasis in adults, particularly for effective tissue repair post-injury. In the intestine, the expansion of the intestinal stem cell (ISC) pool involves both the symmetric division of resident ISCs and the regeneration of ISCs from terminally committed cells through dedifferentiation. We aim to […]

Michael Hoerger, PhD, MSCR, MBA (Psychology) Project Description Our lab conducts health psychology research aimed at 1) reducing the burden of cancer 2) reducing the burden of the COVID-19 pandemic Project Details Time, eligibility, and other details Expected workload varies (contact project organizer) Contact Info mhoerger@tulane.edu Who is eligible Students Additional Info Ideal lab for […]