Heather Machado, School of Medicine
Tissue resident macrophage function has emerged as a critical component controlling the balance between organ health and disease, and disruption of tissue homeostasis can lead to disease. Cancer cells adopt mechanisms to escape immune surveillance, evade growth signals, and others, by participating in complex interactions with healthy immune cells to orchestrate breast cancer progression. The overall goal of this project is to characterize the immune microenvironment in various mouse models of mammary gland development and breast tumorigenesis. Various macrophage subpopulations have been identified by single cell transcriptomics, but their localization and interactions within the tumor microenvironment are unknown. These studies aim to localize diverse macrophage subtypes using multi-plex immunostaining approaches.
| Faculty Supervisor | Heather Machado |
| Project Start Date | 11/01/2024 |
| Number of Spots Available | 1 |
| Project Type | Basic Science |
| Location | On-Site |
| Type of Research | Animal-based, Lab-based, Data Analysis/Write-Up |
| Project Duration | Short-term (weeks to months) |
| Supervisor | Graduate Student |
| Project Expertise | https://medicine.tulane.edu/departments/biochemistry-molecular-biology-tulane-cancer-center/faculty/heather-l-machado-phd |
6-20 hours per week
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