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How do antibacterial agents affect lipid bilayer rigidity and mobility?

Igor Rubtsov, Chemistry

Project Description

We developed an approach of putting a unique vibrational label into a lipid bilayer at a desired depth in the hydrophobic portion of the bilayer. The label is capable of measuring accurately the rigidity of the bilayer via vibrational spectroscopy (FTIR and 2DIR). The project involved testing how the bilayer interior is affected by various antimicrobial agents, both water soluble and hydrophobic.

Check the following reference for more details: Md Muhaiminul Islam, Sithara U. Nawagamuwage, Igor V. Parshin, Margaret C. Richard, Alexander L. Burin, and Igor V. Rubtsov, Probing Hydrophobic Region of a Lipid Bilayer at Specific Depth Using Vibrational Spectroscopy, J. Am. Chem. Soc., 2023, 145, 48, 26363–26373; DOI: 10.1021/jacs.3c10178; The paper is featured in JACS Spotlights, 2023, 145, 48, 25927:

Project Outcome

New results, potential publications.

Project Details

Time, eligibility, and other details

Expected workloadOne full day per week or equivalent. Perform measurements and data analysis.
Skills requiredStrong knowledge in General Chemistry and/or Physics
Who is eligibleSophomore or junior students
Core partnersN/A
Sponsoring partyfaculty
Volunteer, Paid, or Credit-eligible?Volunteering at first; can be credit eligible

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