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Sympathetic Control and Hypertension via Brainstem Cannabinoid Signaling

Andrei Derbenev, PhD, School of Medicine

Lab Description

Central Neural Control of the Autonomic Nervous System: Using whole-cell patch-clamp electrophysiological techniques combined with calcium imaging, neuro-pharmacological, immunochemical, and molecular biological methods, we are conducting studies to determine the synaptic organization, modulation, and plasticity of neuronal networks involved in central neural control of the autonomic nervous system, including cardiovascular function.

Goals of the Lab

  1. Synaptic organization of identified kidney-related neurons in the intermediolateral cell column (IML) of the spinal cord and rostral ventrolateral medulla (RVLM) of the brainstem.
  2. Synaptic organization of the dorsal vagal complex (DVC) of the brainstem.
  3. Neuro-pharmacology of endocannabinoids and endovanilloids.

Contact

aderben@tulane.edu

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