Sean Bong Lee, PhD, School of Medicine
The primary interest of our laboratory is to understand how oncogenic events such as a chromosomal translocation lead to cancer. Ewing’s sarcoma and related small round cell tumors have a distinct characteristic, which involves a chromosomal translocation of the Ewing’s sarcoma gene (EWS) to various transcription factor-encoding genes. The prototype is the EWS-FLI1 translocation found in about 80% of Ewing’s sarcoma. Desmoplastic small round cell tumor (DSRCT) is another chromosomal translocation that leads to the fusion of EWS gene to the WT1 gene.
