Zakaria Abd Elmageed, PhD, School of Medicine
Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in the U.S. Dr. Abd Elmageed’s current research focuses on elucidating the role of signaling and tumor microenvironment on adipose-derived stem cells in prostate cancer (PCa). He is also investigating the differential expression profile of estrogen and its receptors (Alpha/Beta) in PCa based on race, age and genetic background. Tissue microarray (TMA), IHC, proteomics, microRNA arrays and other molecular techniques have been used in tissue culture, on animal models and in human samples to test this hypothesis. Dr. Abd Elmageed’s future research goal is to elucidate the role of miRNAs delivered by cancer-related exosomes in the induction of neoplastic transformation of adipose-derived stem cells into PCa. He also wants to continue to study the tumor microenvironment (niche) growth releasing factors which modulate the transformation of mesenchymal stem cells in vitro and in vivo, as this has the potential for many applications in discovering new therapeutic interventions.
zabdelma@tulane.edu
