Project Description Dr. Liya Pi has focused on the liver and examined reparative processes after local and environmental stresses/injuries. Her research utilizes genetically modified animal models and asks how and why aberrant expression of growth, angiogenic, and fibrotic factors in hepatic microenvironments affects: (1) hepatic progenitor cell activation and ductular reaction, (2) hepatocyte regeneration, (3) […]

Project Description Chronic alcohol abuse has been linked to abnormal epigenetic modifications that affect the progression of alcoholic liver disease (ALD) by influencing factors in controlling cell death in hepatocytes. One such factor is 5-hydroxymethylcytosine (5hmC), but there is currently little information as to how chronic alcohol consumption affects 5hmC’s regulation of cell death. Understanding […]

Project Description Dr. Liya Pi has focused on the liver and examined reparative processes after local and environmental stresses/injuries. Her research utilizes genetically modified animal models and asks how and why aberrant expression of growth, angiogenic, and fibrotic factors in hepatic microenvironments affects: (1) hepatic progenitor cell activation and ductular reaction, (2) hepatocyte regeneration, (3) […]