Sean Bong Lee, PhD, School of Medicine Lab Description The primary interest of our laboratory is to understand how oncogenic events such as a chromosomal translocation lead to cancer. Ewing’s sarcoma and related small round cell tumors have a distinct characteristic, which involves a chromosomal translocation of the Ewing’s sarcoma gene (EWS) to various transcription […]

Loren Gragert, PhD, School of Medicine Lab Information Projects – LCRC Allocation – HLA Bioinformatics Project Contact lgragert@tulane.edu

Srikanta Dash, PhD, School of Medicine Project Overview Hepatitis C virus (HCV) is a positive-strand RNA virus replicate exclusively in the cytoplasm. HCV infection compromises the natural defense mechanism of the liver leading to high rate of chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). The incidence of HCC is expected to be decreased after […]

Project Description My research focuses on induction of protection immunity, typically focusing on mucosal immunity, infection, and adjuvants. My lab uses bacterial ADP-ribosylating enterotoxins derived from E. coli for the manipulation of protective immunity, including the novel adjuvants dmLT and LTA1. In addition, I am interested in host factors and biomarkers of protective immunity, including […]

Project Description The majority of pathogens enter the body through mucosal surfaces. To achieve protection at these sites of entry, my research focuses on vaccine development, particularly investigating non-parenteral (needle-free) immunization techniques. Transcutaneous immunization is one technique that offers many potential benefits over traditional vaccine delivery, including induction of a mucosal immune response. With a […]

Hongwen Deng, PhD (School of Medicine) Project Description Our research group is interested in genetic dissection of human complex diseases using the state-of-the-art multi- and inter-disciplinary approachesof genomic technologies, and statistical and bioinformatical methods. The complex disease we are focusing on is osteoporosis, which is a prevalent,debilitating disorder characterized by bone fragility and an increased […]

Hua Lu, MB (US MS equivalent), PhD (School of Medicine) Project Description The Lu laboratory is interested in understanding the molecular and biochemical basis that underlies physiological and pathological signalingpathways (growth, metabolic, hypoxia, or DNA damage signals), which lead to gene expression and subsequent cell growth arrest, differentiation,senescence, autophagy, or apoptosis. Project Details Time, eligibility, […]

Lab Description Research in my lab is focused on the intrarenal regulation of the RAS in hypertension. My training in molecular genetics and renal physiology with emphasis on experimental hypertension has allowed focusing my efforts on investigating the functional role and the regulation of intrarenal RAS genes in the pathophysiology of hypertension and related renal […]

Lab Description Studies the therapeutic potential of gene therapy in the treatment of AIDS, lysosomal storage diseases, and the use of hematopoietic stem cells. Topics include tissue-specific expression of therapeutic genes and immunomodulatory effects of gene expression. This intersection has clinical relevance for multiple diseases and therapeutic modalities including gene therapy strategies, transplantation, immunotherapy and […]

Project Description Chronic alcohol abuse has been linked to abnormal epigenetic modifications that affect the progression of alcoholic liver disease (ALD) by influencing factors in controlling cell death in hepatocytes. One such factor is 5-hydroxymethylcytosine (5hmC), but there is currently little information as to how chronic alcohol consumption affects 5hmC’s regulation of cell death. Understanding […]