Project Description Our research focuses on the mechanisms of liver injury caused by liver diseases or hepatotoxicity. It includes basic and translational studies on alcohol-associated liver disease (ALD), environmental hepatotoxicity, and metabolic dysfunction-associated steatotic liver disease (MASLD). This project aims to elucidate the mechanisms and roles of bile acid-mediated cell death in the progression of […]

Tong Wu, MD, PhD, School of Medicine Lab Description Dr. Wu’s basic research centers on the molecular mechanisms of inflammation and carcinogenesis, with a special emphasis on the pathogenesis of liver cancer and inflammatory liver diseases. His laboratory focuses on the biological functions and molecular mechanisms of several signaling molecules/cascades including miRNAs, lncRNAs, TGF-beta, Hedgehog, […]

Suzana Savkovic, PhD, School of Medicine Lab Description The main focus of my lab has been to study the role of the transcription factor FOXO3 in inflammation-mediated tumor growth, with a specific focus on the colonic epithelium and colon cancer. First, we have demonstrated that proinflammatory stimuli, such as bacterial products and cytokines, cause a […]

Gilbert Morris, PhD, School of Medicine Lab Description The Morris laboratory is interested in the molecular biology of lung injury and repair with a particular interest in fibrogenesis and carcinogenesis. a. Modeling lung tumorigenesis in mice. Our laboratory has demonstrated expression of the p53 tumor suppressor protein at sites of fibrogenesis after inhalation exposure of […]

Sean Bong Lee, PhD, School of Medicine Lab Description The primary interest of our laboratory is to understand how oncogenic events such as a chromosomal translocation lead to cancer. Ewing’s sarcoma and related small round cell tumors have a distinct characteristic, which involves a chromosomal translocation of the Ewing’s sarcoma gene (EWS) to various transcription […]

Loren Gragert, PhD, School of Medicine Lab Information Projects – LCRC Allocation – HLA Bioinformatics Project Contact lgragert@tulane.edu

Srikanta Dash, PhD, School of Medicine Project Overview Hepatitis C virus (HCV) is a positive-strand RNA virus replicate exclusively in the cytoplasm. HCV infection compromises the natural defense mechanism of the liver leading to high rate of chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). The incidence of HCC is expected to be decreased after […]

Project Description Dr. Liya Pi has focused on the liver and examined reparative processes after local and environmental stresses/injuries. Her research utilizes genetically modified animal models and asks how and why aberrant expression of growth, angiogenic, and fibrotic factors in hepatic microenvironments affects: (1) hepatic progenitor cell activation and ductular reaction, (2) hepatocyte regeneration, (3) […]

Project Description Chronic alcohol abuse has been linked to abnormal epigenetic modifications that affect the progression of alcoholic liver disease (ALD) by influencing factors in controlling cell death in hepatocytes. One such factor is 5-hydroxymethylcytosine (5hmC), but there is currently little information as to how chronic alcohol consumption affects 5hmC’s regulation of cell death. Understanding […]

Project Description Dr. Liya Pi has focused on the liver and examined reparative processes after local and environmental stresses/injuries. Her research utilizes genetically modified animal models and asks how and why aberrant expression of growth, angiogenic, and fibrotic factors in hepatic microenvironments affects: (1) hepatic progenitor cell activation and ductular reaction, (2) hepatocyte regeneration, (3) […]